The Lafaille Lab investigates the immunological mechanisms underlying allergic diseases, with a focus on the generation and persistence of IgE responses. We study how allergic immune memory is established and why allergic diseases persist in some individuals while resolving in others.

Our discoveries of type 2 memory B cells as reservoirs of pathogenic IgE precursors and spleen-resident long-lived IgE plasma cells have provided a new framework for targeting the source of lifelong allergies.